Syracuse () is a city in and the county seat of Onondaga County, New York, United States. It is the fifth-most populous city in the state of New York following New York City, Buffalo, Rochester, and Yonkers.
At the 2010 census, the city population was 145,252, and its metropolitan area had a population of 662,577. It is the economic and educational hub of Central New York, a region with over one million inhabitants. Syracuse is also well-provided with convention sites, with a downtown convention complex. Syracuse was named after the classical Greek city Syracuse (Siracusa in Italian), a city on the eastern coast of the Italian island of Sicily. The city has functioned as a major crossroads over the last two centuries, first between the Erie Canal and its branch canals, then of the railway network. Today, Syracuse is at the intersection of Interstates 81 and 90. Its airport is the largest in the region. Syracuse is home to Syracuse University, a major research university, as well as Le Moyne College, a nationally recognized liberal arts college. French missionaries were the first Europeans to come to this area, arriving to work with the Native Americans in the 1600s.