The airport in Owensboro only operates 2 daily flights to St. Louis (Cape Air) If desired, it would be feasible to fly into Louisville, Ky, and then drive 90 minutes to Owensboro. Or, fly to Nashville, TN, and drive the 2 hours north.
Owensboro is located on U. S. Route 60 and Interstate 165 about 107 miles (172 km) southwest of Louisville, and is the principal city of the Owensboro metropolitan area. The 2018 population was 59,809. The metropolitan population was estimated at 120,702. The metropolitan area is the sixth largest in the state as of 2018, and the seventh largest population center in the state when including micropolitan areas. Evidence of American Indian settlement in the area dates back 12,000 years. Following a series of failed uprisings with British support, however, the last Shawnee were forced to vacate the area before the end of the 18th century. The first European descendant to settle in Owensboro was frontiersman William Smeathers or Smothers in 1797, for whom the riverfront park is named. The settlement was originally known as "Yellow Banks" from the color of the land beside the Ohio River. The Lewis and Clark Expedition wintered at what is today's Owensboro prior to departing on their famous travels.